Barcelona are aiming to win a fourth title in five years.
However, they currently trail fierce rivals Real Madrid by two points at the summit.
Madrid have lost just twice all season, scoring 71 goals along the way, with Barcelona facing a battle to lift the prize.
But, according to Spanish outlet Don Balon, Messi has devised a plan to ensure they triumph come May.
The Argentina international has been in regular correspondence with team-mate Neymar.
Neymar upset several Barcelona players when he missed their 2-1 defeat to Deportivo last month due to the birthday of his sister, Rafaella.
And Messi has been in contact with him about ensuring they maintain top form from now until the end of the season.
The 29-year-old wants Neymar to be at the top of his game if they are to upset the odds and win the title.
He also said that, should they continue to take the division by storm, anything is possible.
Barcelona are eying a treble with Luis Enrique’s side also in contention for the Copa del Rey and Champions League.